BDBM338840 N-{3-[(6R)-4-Amino-6-methyl-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazin-6-yl]-4-fluorophenyl}-4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxamide ::US9751886, Compound 5

SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2nn(cc2Cl)C(F)F)ccc1F

InChI Key InChIKey=DWQBWXKENFEBOL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 338840   

TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338840(US9751886, Compound 5 | N-{3-[(6R)-4-Amino-6-methy...)
Affinity DataIC50: 1.00E+9nMAssay Description:This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338840(US9751886, Compound 5 | N-{3-[(6R)-4-Amino-6-methy...)
Affinity DataIC50: 1.91nMAssay Description:This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338840(US9751886, Compound 5 | N-{3-[(6R)-4-Amino-6-methy...)
Affinity DataIC50: 1.86nMAssay Description:This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay contains the Swedish Lys-Met/Asn-Leu mu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent