BDBM338836 US9751886, Compound 1

SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F

InChI Key InChIKey=ALDQBQZJKOIWIW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 338836   

TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338836(US9751886, Compound 1)
Affinity DataIC50: 5.25nMAssay Description:This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338836(US9751886, Compound 1)
Affinity DataIC50: 4.27nMAssay Description:This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338836(US9751886, Compound 1)
Affinity DataIC50: 3.31nMAssay Description:This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay contains the Swedish Lys-Met/Asn-Leu mu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent