BDBM338411 (3S,6R)-2-[[2,5-difluoro-4- [(1R,4R,5R)-5-(1,2,4-triazol-4-yl)-2- azabicyclo[2.2.1]heptan-2- yl]phenyl]methyl]-3-methyl-6- phenyl-thiazinane 1,1-dioxide::US9751873, Example 99

SMILES C[C@H]1CC[C@H](c2ccccc2)S(=O)(=O)N1Cc1cc(F)c(cc1F)N1C[C@H]2C[C@@H]1C[C@H]2n1cnnc1

InChI Key InChIKey=LDVCUQRTQNORBZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 338411   

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandPNGBDBM338411((3S,6R)-2-[[2,5-difluoro-4- [(1R,4R,5R)-5-(1,2,4-t...)
Affinity DataIC50: 16nMAssay Description:Assays were carried out in 16-microL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent