BDBM337129 US9745291, Compound 175::US9745291, Compound 251::US9765068, Compound 175

SMILES O[C@@H](CNC(=O)CCc1nc2ccccc2[nH]1)CN1CCc2ccccc2C1

InChI Key InChIKey=MZBMFJLRJHAWHN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 337129   

TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

US Patent
LigandPNGBDBM337129(US9765068, Compound 175 | US9745291, Compound 251 ...)
Affinity DataIC50: 100nMAssay Description:Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
US Patent

LigandPNGBDBM337129(US9765068, Compound 175 | US9745291, Compound 251 ...)
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

LigandPNGBDBM337129(US9765068, Compound 175 | US9745291, Compound 251 ...)
Affinity DataIC50: 550nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent