BDBM336814 6-((3-oxopiperazin-1-yl)- methyl)-2-(4-(4-(trifluoro- methyl)phenoxy)phenyl)pyrimidine- 4-carboxamide::US9745287, Compound 27

SMILES NC(=O)c1cc(CN2CCNC(=O)C2)nc(n1)-c1ccc(Oc2ccc(cc2)C(F)(F)F)cc1

InChI Key InChIKey=BGUNVIWWBZPINA-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 336814   

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM336814(6-((3-oxopiperazin-1-yl)- methyl)-2-(4-(4-(trifluo...)
Affinity DataIC50: 72nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM336814(6-((3-oxopiperazin-1-yl)- methyl)-2-(4-(4-(trifluo...)
Affinity DataKi:  80nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent