BDBM336802 2-(3-{[(2R,5R)-2- methyl-5-{[4-(2,2,2- trifluoroethoxy) pyridin-2-yl]oxy} piperidin-1-yl] carbonyl}thiophen 2-yl)pyrimidine::US9745284, 66

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-c1ncccn1)Oc1cc(OCC(F)(F)F)ccn1

InChI Key InChIKey=IEQMJGHQJXJPJI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 336802   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336802(2-(3-{[(2R,5R)-2- methyl-5-{[4-(2,2,2- trifluoroet...)
Affinity DataIC50: 26nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336802(2-(3-{[(2R,5R)-2- methyl-5-{[4-(2,2,2- trifluoroet...)
Affinity DataIC50: 2.08E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent