BDBM336516 (R)-1-(7-fluoro-5-(5- (1,1,1-trifluoro-2- hydroxypropan-2-yl) pyridin-3-yl) indolin-1-l)ethanone::US9745282, 13::US9745282, 14

SMILES CC(=O)N1CCc2cc(cc(F)c12)-c1cncc(c1)C(C)(O)C(F)(F)F

InChI Key InChIKey=FCOBISJZSSLPPO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 336516   

TargetCytochrome P450 11B2, mitochondrial(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336516((R)-1-(7-fluoro-5-(5- (1,1,1-trifluoro-2- hydroxyp...)
Affinity DataIC50: 0.800nMAssay Description:V79 cell lines stably expressing the either the human CYP11B2 or the human CYP11B1 enzyme were generated using a standard transfection protocol. V79 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336516((R)-1-(7-fluoro-5-(5- (1,1,1-trifluoro-2- hydroxyp...)
Affinity DataIC50: 13nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336516((R)-1-(7-fluoro-5-(5- (1,1,1-trifluoro-2- hydroxyp...)
Affinity DataIC50: 2.10nMAssay Description:V79 cell lines stably expressing the either the human CYP11B2 or the human CYP11B1 enzyme were generated using a standard transfection protocol. V79 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336516((R)-1-(7-fluoro-5-(5- (1,1,1-trifluoro-2- hydroxyp...)
Affinity DataIC50: 23nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
Go to US Patent