BDBM336322 (S)-1-(7-chloro-5-(5- (1,1,1,-trifluoro-2- hydroxypropan-2- yl)pydine-3- yl)indolin-1- yl)ethanone::US9745282, 4::US9745282, 5

SMILES CC(=O)N1CCc2cc(cc(Cl)c12)-c1cncc(c1)C(C)(O)C(F)(F)F

InChI Key InChIKey=VFPNOGKANXUTFD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 336322   

TargetCytochrome P450 11B2, mitochondrial(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336322(US9745282, 5 | (S)-1-(7-chloro-5-(5- (1,1,1,-trifl...)
Affinity DataIC50: 1.20nMAssay Description:V79 cell lines stably expressing the either the human CYP11B2 or the human CYP11B1 enzyme were generated using a standard transfection protocol. V79 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336322(US9745282, 5 | (S)-1-(7-chloro-5-(5- (1,1,1,-trifl...)
Affinity DataIC50: 26nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336322(US9745282, 5 | (S)-1-(7-chloro-5-(5- (1,1,1,-trifl...)
Affinity DataIC50: 2.40nMAssay Description:V79 cell lines stably expressing the either the human CYP11B2 or the human CYP11B1 enzyme were generated using a standard transfection protocol. V79 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336322(US9745282, 5 | (S)-1-(7-chloro-5-(5- (1,1,1,-trifl...)
Affinity DataIC50: 53nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
Go to US Patent