BDBM335709 5-(Ethyl(tetrahydro-2H-pyran-4- yl)amino)-N-((5-fluoro-1-methyl- 3-oxo-1,2,3,4- tetrahydroisoquinolin-4- yl)methyl)-4-methyl-4'- (morpholinomethyl)-[1,1'- biphenyl]-3-carboxamide::US9738630, Example 5

SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCC2C(=O)NC(C)c3cccc(F)c23)c1C)-c1ccc(CN2CCOCC2)cc1

InChI Key InChIKey=FUYGRYVZMCQDEP-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 335709   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM335709(US9738630, Example 5 | 5-(Ethyl(tetrahydro-2H-pyra...)
Affinity DataEC50: <5.00E+3nMAssay Description:The effectiveness of compounds of the present invention as inhibitors of hitone methyl transferases can be readily tested by assays known to those sk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
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TargetHistone-lysine N-methyltransferase EZH2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM335709(US9738630, Example 5 | 5-(Ethyl(tetrahydro-2H-pyra...)
Affinity DataIC50: 500nMAssay Description:Inhibition of EZH2 (unknown origin) assessed as reduction in H3K27me3 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed