BDBM335706 5-(Ethyl(tetrahydro-2H-pyran-4- yl)amino)-N-((7-fluoro-1-methyl- 3-oxo-2,3-dihydroisoquinolin-4- yl)methyl)-4-methyl-4''- (morpholinomethyl)-[1,1''- biphenyl]-3-carboxamide::US9738630, Example 13::US9738630, Example 2

SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c3ccc(F)cc3c(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1

InChI Key InChIKey=GSIJWDNZOOMBIX-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 335706   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM335706(US9738630, Example 13 | 5-(Ethyl(tetrahydro-2H-pyr...)
Affinity DataEC50: <50nMAssay Description:The effectiveness of compounds of the present invention as inhibitors of hitone methyl transferases can be readily tested by assays known to those sk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM335706(US9738630, Example 13 | 5-(Ethyl(tetrahydro-2H-pyr...)
Affinity DataEC50: <500nMAssay Description:The effectiveness of compounds of the present invention as inhibitors of hitone methyl transferases can be readily tested by assays known to those sk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent