BDBM335511 US20250049817, Compound 20::US9732097, Example 20::{1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trifluoromethyl) pyridin-2- yl]oxy}cyclohexyl)-3- [4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-1H- pyrazol-1-yl]azetidin- 3-yl}acetonitrile

SMILES CC(C)(O)c1cc(O[C@H]2CC[C@H](CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F

InChI Key InChIKey=JKMHKJRBEGMJBK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 335511   

TargetTyrosine-protein kinase JAK1(Human)
Incyte

US Patent
LigandPNGBDBM335511({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...)
Affinity DataIC50: 10nMAssay Description:The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors were first ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetTyrosine-protein kinase JAK1 [837-1142](Human)
Incyte

US Patent
LigandPNGBDBM335511({1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trif...)
Affinity DataIC50: 10nMAssay Description:JAK1 inhibitors that can be used for the treatment of cytokine-related diseases or disorders are tested for inhibitory activity of JAK targets accord...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2025
Entry Details
Go to US Patent