BDBM335493 (1S,4R,12aS)—N-(2,4-difluorobenzyl)-7-hydroxy-6,8-dioxo-1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1′,2′-d]pyrazine-9-carboxamide::US11548901, Compound 48::US9732092, Compound 48

SMILES Oc1c2C(=O)N3[C@@H]4CC[C@@H](C4)[C@@H]3Cn2cc(C(=O)NCc2ccc(F)cc2F)c1=O

InChI Key InChIKey=WKGDGYMWVQYBAY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 335493   

TargetSolute carrier family 22 member 2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM335493((1S,4R,12aS)—N-(2,4-difluorobenzyl)-7-hydroxy...)
Affinity DataIC50: 4.91E+3nMAssay Description:Test compounds were serially diluted in DMSO and then spiked (2 μL) into in 0.4 mL KHB buffer containing wild-type or OCT2-transfected cells and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetSolute carrier family 22 member 2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM335493((1S,4R,12aS)—N-(2,4-difluorobenzyl)-7-hydroxy...)
Affinity DataIC50: 4.91E+3nMAssay Description:The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
Go to US Patent