BDBM335475 (3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- fluoro-1,5-naphthyridin-4- yl)amino)pyridin-4-yl)-3,6- dimethyl-3,6-dihydro-2H-1,4- thiazine 1,1-dioxide::US9732088, Example 34

SMILES C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2ccnc3cc(F)cnc23)ncc1F

InChI Key InChIKey=HWNAGSUQQMJHQF-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 335475   

TargetBeta-secretase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM335475((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...)
Affinity DataKi:  1.70nMAssay Description:The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetBeta-secretase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM335475((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...)
Affinity DataKi:  8.5nMAssay Description:The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCathepsin D(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM335475((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...)
Affinity DataKi:  4.90E+3nMAssay Description:The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent