BDBM335394 US10717738, Example 60::US9732085, 60::methyl{4-[5-chloro-2-(1-{4-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2-oxo-1(2H)-pyridinyl}propyl)-1H-imidazol-4-yl]phenyl}carbamate

SMILES CCC(c1nc(c(Cl)[nH]1)-c1ccc(NC(=O)OC)cc1)n1ccc(cc1=O)-c1cc(Cl)ccc1-n1cnnn1

InChI Key InChIKey=MQIHJNCSQIUQJM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 335394   

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335394(US9732085, 60 | methyl{4-[5-chloro-2-(1-{4-[5-chlo...)
Affinity DataIC50: 7.20nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335394(US9732085, 60 | methyl{4-[5-chloro-2-(1-{4-[5-chlo...)
Affinity DataIC50: 7.20nMAssay Description:Human Factor XIa activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6000, 50 mM HEPES-NaOH (pH7.4) wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent