BDBM334369 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxyl)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)urea::US9732063, Example 53

SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c(Cl)c3Cl)n2)cc(OC)c1

InChI Key InChIKey=JSARQMZOESQGPT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 334369   

TargetMitogen-activated protein kinase 12(Human)
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LigandPNGBDBM334369(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Affinity DataIC50: 816nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
6/23/2019
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
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LigandPNGBDBM334369(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Affinity DataIC50: 23nMAssay Description:c-Src and Syk Enzyme InhibitionThe inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a...More data for this Ligand-Target Pair
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Date in BDB:
6/23/2019
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TargetTyrosine-protein kinase SYK(Human)
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LigandPNGBDBM334369(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Affinity DataIC50: 56nMAssay Description:c-Src and Syk Enzyme InhibitionThe inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a...More data for this Ligand-Target Pair
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Date in BDB:
6/23/2019
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM334369(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
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Date in BDB:
6/23/2019
Entry Details
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