BDBM333922 8-(1-ethyl-5-methyl-1H-pyrazol- 4-yl)-9-methyl-6-{[(3S)-1- propanoylpyrrolidin-3-yl]oxy}- 9H-purine::US9730940, Compound 2-23

SMILES CCC(=O)N1CC[C@@H](C1)Oc1ncnc2n(C)c(nc12)-c1cnn(CC)c1C

InChI Key InChIKey=MNGYUMAPTXRHRH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 333922   

LigandPNGBDBM333922(8-(1-ethyl-5-methyl-1H-pyrazol- 4-yl)-9-methyl-6-{...)
Affinity DataIC50: 12nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

LigandPNGBDBM333922(8-(1-ethyl-5-methyl-1H-pyrazol- 4-yl)-9-methyl-6-{...)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed