BDBM333811 1-(3-tert- butyl-1-(4- methoxyphenyl)- 1H- pyrazol-5-yl)-3- (3-(6,7- dimethoxy- quinazolin- 4-yloxy) phenyl)urea::US9730937, Example 361

SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cccc(Oc2ncnc3cc(OC)c(OC)cc23)c1)C(C)(C)C

InChI Key InChIKey=IQVJJYJJWIHENX-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 333811   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Ambit Biosciences

US Patent
LigandPNGBDBM333811(1-(3-tert- butyl-1-(4- methoxyphenyl)- 1H- pyrazol...)
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM333811(1-(3-tert- butyl-1-(4- methoxyphenyl)- 1H- pyrazol...)
Affinity DataKd:  375nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM333811(1-(3-tert- butyl-1-(4- methoxyphenyl)- 1H- pyrazol...)
Affinity DataKd:  750nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent