BDBM333449 N-[4-(3-chloro-4- fluorophenylamino)-7-(2-(3-methyl- 3-azabicyclo[3.2.1]octan-8- yl)ethoxy)quinazolin-6-yl]- acrylamide::US10507209, Compound 11::US9730934, Compound 11

SMILES CN1CC2CCC(C1)C2CCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C

InChI Key InChIKey=FGYHOZIXSUEJDM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 333449   

TargetEpidermal growth factor receptor(Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM333449(N-[4-(3-chloro-4- fluorophenylamino)-7-(2-(3-methy...)
Affinity DataIC50: 0.800nMAssay Description:Assay Procedures:The abbreviations used in the following assay have the following meanings:HEPES: hydroxyethyl piperazine ethanesulfonic acid;Brij-35...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetReceptor tyrosine-protein kinase erbB-2(Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM333449(N-[4-(3-chloro-4- fluorophenylamino)-7-(2-(3-methy...)
Affinity DataIC50: 12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM333449(N-[4-(3-chloro-4- fluorophenylamino)-7-(2-(3-methy...)
Affinity DataIC50: 8.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM333449(N-[4-(3-chloro-4- fluorophenylamino)-7-(2-(3-methy...)
Affinity DataIC50: 0.800nMAssay Description:Samples:Controls: Gefitinib, erlotinib hydrochloride, purchased from Anqing worldchem Co., LTD.; lapatinib ditosylate, purchased from Taizhou Xingche...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM333449(N-[4-(3-chloro-4- fluorophenylamino)-7-(2-(3-methy...)
Affinity DataIC50: 12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM333449(N-[4-(3-chloro-4- fluorophenylamino)-7-(2-(3-methy...)
Affinity DataIC50: 8.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent