BDBM333411 5-(2,4-Difluorophenoxy)-1,3-dimethyl-6-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one::US9737516, Example 7

SMILES Cn1c2cc(Oc3ccc(F)cc3F)c(cc2n(C)c1=O)-c1cn(C)c(=O)c2[nH]ccc12

InChI Key InChIKey=KATWSYZUHCICQF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 333411   

TargetBromodomain-containing protein 4 [368-440](Human)
Incyte

US Patent
LigandPNGBDBM333411(5-(2,4-Difluorophenoxy)-1,3-dimethyl-6-(6-methyl-7...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Incyte

US Patent
LigandPNGBDBM333411(5-(2,4-Difluorophenoxy)-1,3-dimethyl-6-(6-methyl-7...)
Affinity DataIC50: 550nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
US Patent