BDBM333178 US10196436, Compound 28

SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cc(C)cc3NC(=O)C=C)ncc2c1

InChI Key InChIKey=OEHRSXJVWNJIGB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 333178   

TargetFibroblast growth factor receptor 4(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM333178(US10196436, Compound 28)
Affinity DataIC50: 55nMAssay Description:In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM333178(US10196436, Compound 28)
Affinity DataIC50: 1.00E+3nMAssay Description:In each well of a 384-well plate, 0.1 ng/ul of wild type FGFR-1 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM333178(US10196436, Compound 28)
Affinity DataIC50: 91nMAssay Description:Inhibition of N-terminal GST fusion tagged human FGFR4 cytoplasmic domain (460 to 802 end residues) expressed in baculovirus expression system preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed