BDBM332760 US10196383, Example 5

SMILES Cc1ccc(c(c1)C(=O)N1CCCN(CC1)c1nc2ccc(Cl)cc2c(=O)[nH]1)-n1nccn1

InChI Key InChIKey=PKNMJDVLHAXVPL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332760   

TargetOrexin/Hypocretin receptor type 1(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM332760(US10196383, Example 5)
Affinity DataIC50: 276nMAssay Description:The capability of the compounds to the antagonism of humanized OX1 receptor transfected to the Chinese hamster ovary (CHO) cells was evaluated by the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM332760(US10196383, Example 5)
Affinity DataIC50: 263nMAssay Description:The capability of the compounds to antagonism of humanized OX2 receptor transfected by the HEK-293 cells was evaluated by the method of fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent