BDBM332759 US10196383, Example 2

SMILES CC1CCN(CCN1C(=O)c1cc(C)ccc1-n1nccn1)c1nc2ccc(F)cc2c(=O)[nH]1

InChI Key InChIKey=MFZZJRHFSGBOQY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332759   

TargetOrexin/Hypocretin receptor type 1(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM332759(US10196383, Example 2)
Affinity DataIC50: 543nMAssay Description:The capability of the compounds to the antagonism of humanized OX1 receptor transfected to the Chinese hamster ovary (CHO) cells was evaluated by the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM332759(US10196383, Example 2)
Affinity DataIC50: 169nMAssay Description:The capability of the compounds to antagonism of humanized OX2 receptor transfected by the HEK-293 cells was evaluated by the method of fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent