BDBM332705 US10196378, Compound C08

SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccc4ncncc4c3)cc2)n(n1)-c1ccc2ncccc2c1

InChI Key InChIKey=VZSXRPCZRQJQFY-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 332705   

TargetTyrosine-protein kinase ABL1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM332705(US10196378, Compound C08)
Affinity DataIC50: 65nMAssay Description:Inhibition of NanoLuc-tagged ABL1 wild type (unknown origin) expressed in HEK293 cells by NanoBRET TE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM332705(US10196378, Compound C08)
Affinity DataKi:  0.960nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL1 [Y253F](Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332705(US10196378, Compound C08)
Affinity DataKi:  3.40nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332705(US10196378, Compound C08)
Affinity DataKi:  518nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent