BDBM332701 US10196378, Compound C04

SMILES CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Nc4ccc5ncccc5c4)cc3)cc2C(F)(F)F)CC1

InChI Key InChIKey=ZCSPZLWIKBOUKI-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 332701   

TargetTyrosine-protein kinase ABL1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332701(US10196378, Compound C04)
Affinity DataKi:  1.70nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332701(US10196378, Compound C04)
Affinity DataKi:  1.70nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL1 [T315I](Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332701(US10196378, Compound C04)
Affinity DataKi:  2.10nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL1 [Y253F](Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332701(US10196378, Compound C04)
Affinity DataKi:  50nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332701(US10196378, Compound C04)
Affinity DataKi:  4.50E+3nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent