BDBM332678 US10196374, Example 6

SMILES CC(C)[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1cccc(Cl)c1

InChI Key InChIKey=DPAAYBADQOGZSY-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 332678   

TargetGlucocorticoid receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM332678(US10196374, Example 6)
Affinity DataEC50:  2.51nMAssay Description:A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma cell line, ChaGo K1 (ATCC: HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetGlucocorticoid receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM332678(US10196374, Example 6)
Affinity DataIC50: 50.1nMAssay Description:A reporter cell line (ChagoK1 18:7:2 s4/GRE) was established by stable transfection of the human bronchogenic carcinoma celline, ChaGo K1 (ATCC: HTB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Astrazeneca

US Patent
LigandPNGBDBM332678(US10196374, Example 6)
Affinity DataIC50: 398nMAssay Description:TNFα protein levels were determined using an AlphaLISA hTNFa kit (Perkin Elmer) according to the manufacturer's instructions. Briefly, the s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetGlucocorticoid receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM332678(US10196374, Example 6)
Affinity DataIC50: 3nMAssay Description:Transrepression activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells assessed as inhibition of PMA-stimulated gene e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM332678(US10196374, Example 6)
Affinity DataIC50: 420nMAssay Description:Transrepression of GR in human whole blood assessed as inhibition of LPS-induced TNF-alpha release preincubated for 45 mins followed by LPS addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM332678(US10196374, Example 6)
Affinity DataEC50:  5.60nMAssay Description:Transactivation activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells incubated for 24 hrs by beta-galactosidase repo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM332678(US10196374, Example 6)
Affinity DataIC50: 114nMAssay Description:Antagonist activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells assessed as inhibition of dexamethasone induced tran...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM332678(US10196374, Example 6)
Affinity DataIC50: 3nMAssay Description:Displacement of fluormone RED from human full length glucocorticoid receptor after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed