BDBM33261 biguanidine, 1

SMILES [#7]\[#6](-[#7])=[#7]\[#7]=[#6]-c1ccc(-[#6]=[#7]\[#7]=[#6](\[#7])-[#7])cc1

InChI Key InChIKey=BQCSHQINHFIIFA-UHFFFAOYSA-N

Data  5 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 33261   

TargetSortase family protein(Staphylococcus aureus)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM33261(biguanidine, 1)
Affinity DataIC50: 2.75E+5nMAssay Description:Inhibition of Staphylococcus aures sortase A by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFurin(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM33261(biguanidine, 1)
Affinity DataKi:  1.47E+3nMAssay Description:Inhibition of human recombinant furin by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](WNV)
University of Alabama At Birmingham

LigandPNGBDBM33261(biguanidine, 1)
Affinity DataKi:  3.50E+4nM ΔG°:  -6.03kcal/molepH: 8.5 T: 2°CAssay Description:All proteases were assayed by monitoring the cleavage of peptide substrate with fluorescent reporter at room temperature with a microtiter plate spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
University of Alabama At Birmingham

LigandPNGBDBM33261(biguanidine, 1)
Affinity DataKi:  4.40E+4nM ΔG°:  -5.90kcal/molepH: 8.5 T: 2°CAssay Description:All proteases were assayed by monitoring the cleavage of peptide substrate with fluorescent reporter at room temperature with a microtiter plate spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM33261(biguanidine, 1)
Affinity DataKi:  6.80E+4nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
University of Alabama At Birmingham

LigandPNGBDBM33261(biguanidine, 1)
Affinity DataKi:  8.70E+4nM ΔG°:  -5.50kcal/molepH: 7.6 T: 2°CAssay Description:All proteases were assayed by monitoring the cleavage of peptide substrate with fluorescent reporter at room temperature with a microtiter plate spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed