BDBM332545 (E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(2-ethoxyethoxy)quinazolin-6-yl)-4-(diethylamino)but-2-enamide ::US10196365, Compound 33

SMILES CCOCCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C/Cl

InChI Key InChIKey=NJHDYUHKGOBVKW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332545   

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

US Patent
LigandPNGBDBM332545(US10196365, Compound 33 | (E)-N-(4-(3-chloro-4-flu...)
Affinity DataIC50: 1.49nMAssay Description:The kinase analysis in vitro was performed using the HTRF kinEASE TK kit of Invitrogen Co., the procedure steps were carried out according to instruc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

US Patent
LigandPNGBDBM332545(US10196365, Compound 33 | (E)-N-(4-(3-chloro-4-flu...)
Affinity DataIC50: 10.9nMAssay Description:The kinase analysis in vitro was performed using the HTRF kinEASE TK kit of Invitrogen Co., the procedure steps were carried out according to instruc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent