BDBM332542 (E)-N-(7-(2-ethoxyethoxy)-4-(3-ethynylphenylamino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide ::US10196365, Compound 10

SMILES CCOCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1NC(=O)\C=C\CN(C)C

InChI Key InChIKey=IFUPZYWAOYZTHS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332542   

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

US Patent
LigandPNGBDBM332542(US10196365, Compound 10 | (E)-N-(7-(2-ethoxyethoxy...)
Affinity DataIC50: 0.771nMAssay Description:The kinase analysis in vitro was performed using the HTRF kinEASE TK kit of Invitrogen Co., the procedure steps were carried out according to instruc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

US Patent
LigandPNGBDBM332542(US10196365, Compound 10 | (E)-N-(7-(2-ethoxyethoxy...)
Affinity DataIC50: 3.63nMAssay Description:The kinase analysis in vitro was performed using the HTRF kinEASE TK kit of Invitrogen Co., the procedure steps were carried out according to instruc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent