BDBM332536 (E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(3-methoxypropoxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide ::US10196365, Compound 1

SMILES COCCCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C

InChI Key InChIKey=ASJKJRLGRZGMDR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 332536   

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

US Patent
LigandPNGBDBM332536(US10196365, Compound 1 | (E)-N-(4-(3-chloro-4-fluo...)
Affinity DataIC50: 0.765nMAssay Description:The kinase analysis in vitro was performed using the HTRF kinEASE TK kit of Invitrogen Co., the procedure steps were carried out according to instruc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

US Patent
LigandPNGBDBM332536(US10196365, Compound 1 | (E)-N-(4-(3-chloro-4-fluo...)
Affinity DataIC50: 39.3nMAssay Description:The kinase analysis in vitro was performed using the HTRF kinEASE TK kit of Invitrogen Co., the procedure steps were carried out according to instruc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

US Patent
LigandPNGBDBM332536(US10196365, Compound 1 | (E)-N-(4-(3-chloro-4-fluo...)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of recombinant human GST-tagged EGFR catalytic domain (668 to 1210 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

US Patent
LigandPNGBDBM332536(US10196365, Compound 1 | (E)-N-(4-(3-chloro-4-fluo...)
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant human His-tagged HER2 catalytic domain (676 to 1255 residues) expressed in baculovirus expression system using TK-biotin pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed