BDBM332492 4-(6-[4- (aminomethyl) pyridin-2-yl]-1- {[2-chloro-6- (trifluoromethyl) phenyl]carbonyl}- 1H-indazol-3- yl)benzoic acid::US10196354, Example 22H::US9745265, 22H

SMILES NCc1ccnc(c1)-c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1)C(O)=O

InChI Key InChIKey=XSLPFBFEJUJHTN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332492   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332492(US10196354, Example 22H | 4-(6-[4- (aminomethyl) p...)
Affinity DataIC50: 37nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332492(US10196354, Example 22H | 4-(6-[4- (aminomethyl) p...)
Affinity DataIC50: 37nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent