BDBM330393 US9725436, Entry 12

SMILES CC(C)S(=O)(=O)N1CCN(CC1)c1ccc(\C=C\c2cc(F)cc(Cn3ccnc3)c2)cc1

InChI Key InChIKey=PJUHXZOBWSJDFF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 330393   

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Bovine)
Cortendo AB (PUBL)

US Patent
LigandPNGBDBM330393(US9725436, Entry 12)
Affinity DataIC50: 39nMAssay Description:Cyp17 assay protocol: AD293 cells that stably over-express recombinant CYP-17 were seeded in 96 well plates coated with poly D-lysine (15,000 cell pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
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TargetCholesterol side-chain cleavage enzyme, mitochondrial(Bovine)
Cortendo AB (PUBL)

US Patent
LigandPNGBDBM330393(US9725436, Entry 12)
Affinity DataIC50: 5nMAssay Description:Cyp11 assay protocol: AD293 cells that stably over-express recombinant CYP-11 were seeded in 96 well plates coated with poly D-lysine (15,000 cell pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Bovine)
Cortendo AB (PUBL)

US Patent
LigandPNGBDBM330393(US9725436, Entry 12)
Affinity DataIC50: 700nMAssay Description:Cyp21 assay protocol: AD293 cells that stably over-express recombinant CYP-21 were seeded in 96 well plates coated with poly D-lysine (10,000 cell pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM330393(US9725436, Entry 12)
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) expressed in human AD293 cells using [21-3H]17alpha-hydroxypregnenolone as substrate preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details Article
PubMed