BDBM330294 Ethyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate ::US9724352, I-32

SMILES CCOC(=O)Nc1cc(c(cn1)-c1nc(N2CCOCC2)c2cc(CN3CCN(CC3)S(C)(=O)=O)cn2n1)C(F)(F)F

InChI Key InChIKey=VDDZOFLILWFGHD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 330294   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM330294(US9724352, I-32 | Ethyl (5-(6-((4-(methylsulfonyl)...)
Affinity DataIC50: 7.15nMAssay Description:The activity of purified kinase was detected with Kinase-Glo Plus kinase luminescent assay by measuring the amount of the remaining Kinase in the sol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

LigandPNGBDBM330294(US9724352, I-32 | Ethyl (5-(6-((4-(methylsulfonyl)...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed