BDBM330258 1-(4-(4-methylpiperazine-carbonyl)phenyl)-3-(4-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)phenyl)urea::US9724352, I-22

SMILES CN1CCN(CC1)C(=O)c1ccc(NC(=O)Nc2ccc(cc2)-c2nc(N3CCOCC3)c3cc(CN4CCN(CC4)S(C)(=O)=O)cn3n2)cc1

InChI Key InChIKey=JEOYRMKVSITIGT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 330258   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM330258(US9724352, I-22 | 1-(4-(4-methylpiperazine-carbony...)
Affinity DataIC50: 9.59nMAssay Description:The activity of purified kinase was detected with Kinase-Glo Plus kinase luminescent assay by measuring the amount of the remaining Kinase in the sol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

LigandPNGBDBM330258(US9724352, I-22 | 1-(4-(4-methylpiperazine-carbony...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed