BDBM329696 Preparation of 1-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)pyrrolidine-3-carboxylic acid (1C)::US9663522, 1C::US9663522, 2A

SMILES OC(=O)C1CCN(C1)c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cccc(F)c12

InChI Key InChIKey=IRIVFWGAKIUHGT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 329696   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM329696(US9663522, 1C | US9663522, 2A | Preparation of 1-(...)
Affinity DataIC50: 6.70E+3nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM329696(US9663522, 1C | US9663522, 2A | Preparation of 1-(...)
Affinity DataIC50: 10nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent