BDBM329454 2,2-difluoro-1-(5-(4- (((1S,2S)-2-(5- methoxypyridin-2- yl)cyclopropyl)methoxy)- 2-methylpyrimidin-5- yl)pyridin-2-yl)ethanol (R or S)::US9663513, 67::US9663513, 68

SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C(O)C(F)F

InChI Key InChIKey=QNESJXSBSQJCLH-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 329454   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM329454(US9663513, 67 | 2,2-difluoro-1-(5-(4- (((1S,2S)-2-...)
Affinity DataKi:  0.100nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM329454(US9663513, 67 | 2,2-difluoro-1-(5-(4- (((1S,2S)-2-...)
Affinity DataKi:  0.430nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent