BDBM329427 5-(3-ethoxyphenyl)-2- methyl-6-(((1S,2S)-2- (quinolin-2- yl)cyclopropyl)methoxy) pyrimidin-1-ium 2,2,2- trifluoroacetate (enantiomer A)::US9663513, 40::US9663513, 41

SMILES CCOc1cccc(c1)-c1cnc(C)[nH+]c1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1

InChI Key InChIKey=GWOCNAQGMAATMQ-UHFFFAOYSA-O

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 329427   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM329427(US9663513, 41 | 5-(3-ethoxyphenyl)-2- methyl-6-(((...)
Affinity DataKi:  0.0400nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM329427(US9663513, 41 | 5-(3-ethoxyphenyl)-2- methyl-6-(((...)
Affinity DataKi:  5.08nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent