BDBM329062 4-(5-cyano-6-(3,5- dichlorophenoxy)-3-pyridinyl)- 3-methoxy-N- (methylsulfonyl)benzamide::4-(5-cyano-6-(3,5-dichlorophenoxy)-3-pyridinyl)-3-methoxy-N-(methylsulfonyl)benzamide::US9663508, Example 547

SMILES COc1cc(ccc1-c1cnc(Oc2cc(Cl)cc(Cl)c2)c(c1)C#N)C(=O)NS(C)(=O)=O

InChI Key InChIKey=IMPGUFQVHAXJGI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 329062   

LigandPNGBDBM329062(US9663508, Example 547 | 4-(5-cyano-6-(3,5-dichlor...)
Affinity DataIC50: 77.1nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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LigandPNGBDBM329062(US9663508, Example 547 | 4-(5-cyano-6-(3,5-dichlor...)
Affinity DataIC50: 77nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329062(US9663508, Example 547 | 4-(5-cyano-6-(3,5-dichlor...)
Affinity DataIC50: 1.61E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed