BDBM328997 1137478-45-5::US11787792, Compound Y-152::US9663503, Compound Y-152

SMILES Cn1cc(cn1)-c1cnc(Nc2cnc(cn2)C#N)cc1NC[C@@H]1CNCCO1

InChI Key InChIKey=HGYKCQUYMKJVQI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 328997   

TargetSerine/threonine-protein kinase Chk1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM328997(US9663503, Compound Y-152 | 1137478-45-5 | US11787...)
Affinity DataIC50: 2nMAssay Description:CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM328997(US9663503, Compound Y-152 | 1137478-45-5 | US11787...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM328997(US9663503, Compound Y-152 | 1137478-45-5 | US11787...)
Affinity DataIC50: 400nMAssay Description:Inhibition of CHK1 in human HT-29 cells assessed as abrogation of etoposide-induced G2 checkpoint arrest by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM328997(US9663503, Compound Y-152 | 1137478-45-5 | US11787...)
Affinity DataIC50: 2.20E+4nMAssay Description:Displacement of [3H]astemizole from human ERG expressed in HEK293 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM328997(US9663503, Compound Y-152 | 1137478-45-5 | US11787...)
Affinity DataIC50: 2nMAssay Description:CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent