BDBM328993 5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile::US11787792, Compound 1::US9663503, Compound 1

SMILES FC(F)(F)c1cnc(Nc2cnc(cn2)C#N)cc1NC[C@H]1CNCCO1

InChI Key InChIKey=YBYYWUUUGCNAHQ-UHFFFAOYSA-N

Data  23 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 328993   

LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Kv1.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 910nMAssay Description:Inhibition of wildtype FLT3 (unknown origin) using peptide substrate incubated for 1 hrs in presence of ATP by fluorescence microplate reader analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 26nMAssay Description:Inhibition of CHK1 (unknown origin) using peptide substrate incubated for 1 hrs in presence of ATP by fluorescence microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.97E+3nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) using peptide substrate incubated for 1 hrs in presence of ATP by fluorescence microplate reader ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 29nMAssay Description:Inhibition of CHK1 (unknown origin) using peptide substrate S1 and ATP as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.40nMAssay Description:CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HCN4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human KCNQ1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Kv4.3More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetInward rectifier potassium channel 2(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Kir2.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human L-type calcium channel Cav1.2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Nav1.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.40nMAssay Description:CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2A6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 6.20E+3nMAssay Description:Displacement of [3H]astemizole from human ERG expressed in HEK293 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 30nMAssay Description:Inhibition of CHK1 in human HT-29 cells assessed as abrogation of etoposide-induced G2 checkpoint arrest by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 2nMAssay Description:Inhibition of CHK1 (unknown origin) using Cdc25 peptide as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed