BDBM3289 4-(Benzylamino)quinazoline deriv. 40::CHEMBL545541::N-benzyl-6,7-dimethoxyquinazolin-4-amine

SMILES COc1cc2ncnc(NCc3ccccc3)c2cc1OC

InChI Key InChIKey=FVWVAEZYXLGVIV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 3289   

TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM3289(N-benzyl-6,7-dimethoxyquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50: 10nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2005
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3289(N-benzyl-6,7-dimethoxyquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article

TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM3289(N-benzyl-6,7-dimethoxyquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation, 0.05-0.10More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article