BDBM328742 1,1,1-trifluoro-2-methylpropan- 2-yl ((S)-2-(((1R,2S)-2- cyanocyclopropane- carboxamido)methyl)-4-((4- fluorophenyl)sulfonyl)-3,4- dihydro-2H- benzo[b][1,4]oxazin-6- yl)carbamate::US9663502, 34AU

SMILES CC(C)(OC(=O)Nc1ccc2O[C@@H](CNC(=O)[C@@H]3C[C@@H]3C#N)CN(c2c1)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F

InChI Key InChIKey=MLHOZCZKFZNJFS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 328742   

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM328742(US9663502, 34AU | 1,1,1-trifluoro-2-methylpropan- ...)
Affinity DataIC50: 3.94nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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