BDBM328391 6-chloro-3-(difluoromethyl)-1-((4-methoxy-3-(piperazin-1-yl) phenyl)sulfonyl)-1H-indole::US9663498, Example 31

SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2ccc(Cl)cc12

InChI Key InChIKey=CLJDTPHSRUGUPY-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 328391   

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 0.0850nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 6.20nMAssay Description:Antagonist activity at recombinant human 5HT6R expressed in CHO cells assessed as inhibition of 5HT-stimulated cAMP accumulation incubated for 4 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes preincubated for 10 mins followed by NADPH addition and measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes preincubated for 10 mins followed by NADPH addition and measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes preincubated for 10 mins followed by NADPH addition and measured after 45 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes preincubated for 10 mins followed by NADPH addition and measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 4.02E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes preincubated for 10 mins followed by NADPH addition and measured after 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataKi:  0.0850nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed