BDBM328389 3-(difluoromethyl)-6-fluoro-1-((4-methoxy-3-(piperazin-1-yl) phenyl)sulfonyl)-1H-indole::US9663498, Example 29

SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2ccc(F)cc12

InChI Key InChIKey=NVURPAJUKWGEBE-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 328389   

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328389(US9663498, Example 29 | 3-(difluoromethyl)-6-fluor...)
Affinity DataIC50: 0.260nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328389(US9663498, Example 29 | 3-(difluoromethyl)-6-fluor...)
Affinity DataIC50: 7.10nMAssay Description:Antagonist activity at recombinant human 5HT6R expressed in CHO cells assessed as inhibition of 5HT-stimulated cAMP accumulation incubated for 4 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328389(US9663498, Example 29 | 3-(difluoromethyl)-6-fluor...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed