BDBM328315 N-((3S,4S)-1-(4- cyanobenzyl)-3- fluoropiperidin-4-yl)-6- (4-(4-methoxybenzoyl) piperidine-1- carbonyl)nicotinamide::US10377742, Compound 453::US9663496, Compound 453

SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@H]1CCN(Cc2ccc(cc2)C#N)C[C@@H]1F

InChI Key InChIKey=LEUSDRGCPVXECX-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 328315   

Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM328315(US9663496, Compound 453 | N-((3S,4S)-1-(4- cyanobe...)
Affinity DataEC50: <500nMAssay Description:Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM328315(US9663496, Compound 453 | N-((3S,4S)-1-(4- cyanobe...)
Affinity DataEC50: <500nMAssay Description:Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

Target5'-AMP-activated protein kinase subunit gamma-3(Mouse)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM328315(US9663496, Compound 453 | N-((3S,4S)-1-(4- cyanobe...)
Affinity DataEC50:  161nMAssay Description:Activation of AMPK in mouse C2C12 cells incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed