BDBM328171 N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- methoxybenzoyl) piperidine-1- carbonyl)nicotinamide::US10377742, Compound 309::US9663496, Compound 309

SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1

InChI Key InChIKey=JKGJLUCJLNJXKG-UHFFFAOYSA-N

Data  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 328171   

Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM328171(US9663496, Compound 309 | N-(1-(4- cyanobenzyl)pip...)
Affinity DataEC50: <500nMAssay Description:Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM328171(US9663496, Compound 309 | N-(1-(4- cyanobenzyl)pip...)
Affinity DataEC50: <500nMAssay Description:Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM328171(US9663496, Compound 309 | N-(1-(4- cyanobenzyl)pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM328171(US9663496, Compound 309 | N-(1-(4- cyanobenzyl)pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5'-AMP-activated protein kinase subunit gamma-3(Mouse)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM328171(US9663496, Compound 309 | N-(1-(4- cyanobenzyl)pip...)
Affinity DataEC50:  137nMAssay Description:Activation of AMPK in mouse C2C12 cells incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed