BDBM326323 4-(5-chloropyridin-3-yl)-5- [(trans-4- methylcyclohexyl)methyl]- 7-(2-methylpropyl)-5H- pyrrolo[3,2-d]pyrimidine- 2-carboxylic acid::US9637493, 5.7

SMILES CC(C)Cc1cn(C[C@H]2CC[C@H](C)CC2)c2c(nc(nc12)C(O)=O)-c1cncc(Cl)c1

InChI Key InChIKey=MRNYDPUXQGVJLN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326323   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326323(4-(5-chloropyridin-3-yl)-5- [(trans-4- methylcyclo...)
Affinity DataIC50: 71nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent