BDBM3263 4-Anilino quinazoline deriv. 14::CHEMBL329672::CHEMBL555321::N-(3-chlorophenyl)quinazolin-4-amine

SMILES Clc1cccc(Nc2ncnc3ccccc23)c1

InChI Key InChIKey=ZKKVUIPXPPDIRD-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 3263   

TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3263(CHEMBL329672 | N-(3-chlorophenyl)quinazolin-4-amin...)
Affinity DataIC50: 23nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3263(CHEMBL329672 | N-(3-chlorophenyl)quinazolin-4-amin...)
Affinity DataIC50: 23nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3263(CHEMBL329672 | N-(3-chlorophenyl)quinazolin-4-amin...)
Affinity DataIC50: 23nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3263(CHEMBL329672 | N-(3-chlorophenyl)quinazolin-4-amin...)
Affinity DataIC50: 4.16E+3nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3263(CHEMBL329672 | N-(3-chlorophenyl)quinazolin-4-amin...)
Affinity DataIC50: 23nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAcyl-CoA (8-3)-desaturase(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM3263(CHEMBL329672 | N-(3-chlorophenyl)quinazolin-4-amin...)
Affinity DataIC50: 11nMAssay Description:Inhibition of liver delta-5 desaturase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3263(CHEMBL329672 | N-(3-chlorophenyl)quinazolin-4-amin...)
Affinity DataIC50: 50nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation, 0.05-0.10More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article

TargetTyrosine-protein kinase Lck(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM3263(CHEMBL329672 | N-(3-chlorophenyl)quinazolin-4-amin...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of p56lck kinase autophosphorylation in Jurkat cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article