BDBM326216 (2R)-1-[(2S,5R)-5-{7-amino-1-[4-(3-fluorophenoxy)phenyl]-1H-pyrazolo[3,4-c]pyridin-3-yl}-2-methylpiperidin-1-yl]-1-oxopropan-2-ol::US9637486, Example 29

SMILES C[C@@H](O)C(=O)N1C[C@@H](CC[C@@H]1C)c1nn(-c2ccc(Oc3cccc(F)c3)cc2)c2c(N)nccc12

InChI Key InChIKey=CNNXAWQNTUVDQH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326216   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326216((2R)-1-[(2S,5R)-5-{7-amino-1-[4-(3-fluorophenoxy)p...)
Affinity DataIC50: 5.80nMAssay Description:In this assay, the potency (IC50) of each compound was determined from an eleven point (1:3 serial dilution; final compound concentration range in as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
Go to US Patent