BDBM326211 3-[(3R)-1- acryloylpiperidin-3-yl]-1- (4-phenoxyphenyl)-1H- pyrazolo[3,4-c]pyridin-7- amine::US11739090, Compound 7A::US9637486, Example 23

SMILES Nc1nccc2c(nn(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C

InChI Key InChIKey=BIRLBQULISTSMZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 326211   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326211(3-[(3R)-1- acryloylpiperidin-3-yl]-1- (4-phenoxyph...)
Affinity DataIC50: 0.660nMAssay Description:In this assay, the potency (IC50) of each compound was determined from an eleven point (1:3 serial dilution; final compound concentration range in as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
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TargetEpidermal growth factor receptor(Human)
Jumbo Drug Bank

US Patent
LigandPNGBDBM326211(3-[(3R)-1- acryloylpiperidin-3-yl]-1- (4-phenoxyph...)
Affinity DataIC50: 14.5nMAssay Description:1. Reaction conditions: buffer conditions: 20 mM HEPES (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mm Na3VO4, 2 mm DTT, 1% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
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TargetTyrosine-protein kinase ITK/TSK(Human)
Jumbo Drug Bank

US Patent
LigandPNGBDBM326211(3-[(3R)-1- acryloylpiperidin-3-yl]-1- (4-phenoxyph...)
Affinity DataIC50: 42.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
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TargetTyrosine-protein kinase Tec(Human)
Jumbo Drug Bank

US Patent
LigandPNGBDBM326211(3-[(3R)-1- acryloylpiperidin-3-yl]-1- (4-phenoxyph...)
Affinity DataIC50: 3.39nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326211(3-[(3R)-1- acryloylpiperidin-3-yl]-1- (4-phenoxyph...)
Affinity DataIC50: 0.730nMAssay Description:1. Reaction conditions: buffer conditions: 20 mM HEPES (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mm Na3VO4, 2 mm DTT, 1% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent