BDBM325597 1-Isopropyl-3-[5-(1-isopropyl-piperidin-4-yl)-[1,3,4]oxadiazol-2-yl]-1H-indazole::US9636335, 38

SMILES CC(C)N1CCC(CC1)c1nnc(o1)-c1nn(C(C)C)c2ccccc12

InChI Key InChIKey=HUYJRMFAFYNTRY-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 325597   

Target5-hydroxytryptamine receptor 4(Human)
Suven Life Sciences

US Patent
LigandPNGBDBM325597(1-Isopropyl-3-[5-(1-isopropyl-piperidin-4-yl)-[1,3...)
Affinity DataEC50:  23nMAssay Description:A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 4(Human)
Suven Life Sciences

US Patent
LigandPNGBDBM325597(1-Isopropyl-3-[5-(1-isopropyl-piperidin-4-yl)-[1,3...)
Affinity DataEC50:  23nMAssay Description:Partial agonist activity at human 5HT4E receptor expressed in CHO cells assessed as cAMP accumulation incubated for 4 hrs by luciferase reporter gene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM325597(1-Isopropyl-3-[5-(1-isopropyl-piperidin-4-yl)-[1,3...)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 2 mins in presence of NADPH regenerating system by LC-MS/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM325597(1-Isopropyl-3-[5-(1-isopropyl-piperidin-4-yl)-[1,3...)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 12 mins in presence of NADPH regenerating system by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed